Human Chorionic Gonadotropin (hCG) Medication Monograph

hCG stands for Human Chorionic Gonadotropin. hCG is produced naturally by the placenta in pregnant women after egg implantation. When administered exogenously, hCG acts like luteinizing hormone in the body

Indications: In males, luteinizing hormone works on the testes, stimulating the natural production of testosterone and sperm as well as helping preserve fertility for those using testosterone therapy. In females, luteinizing hormone stimulates ovulation. Therefore, hCG injections can help both males and females with fertility

Dosing (Adults): Hypogonadotropic hypogonadism: Males: Various regimensSpermatogenesis induction associated with hypogonadotropic hypogonadism (off-label use):Males: 1,000 to 3,000 units 2 to 3 times/weekOvulation induction: Females: 5,000 to 10,000 units 1 day following last dose of menotropins

Common Dosing: Males: Inject 500-3000 IU subcutaneously 2-3 times per week

Renal Dosing: There are no dosage adjustments provided in the manufacturer’s labeling; use with caution

Hepatic Impairment: There are no dosage adjustments provided in the manufacturer’s labeling (not studied)

Contraindications: Hypersensitivity to chorionic gonadotropin or any component of the formulation; precocious puberty; prostatic carcinoma or other androgen-dependent neoplasms

Warnings/Precautions:

Hypersensitivity: Anaphylaxis has been reported with urinary-derived hCG products

Thromboembolism: Arterial or venous thromboembolism may occur; patients with a history of family history of thrombosis, severe obesity, or thrombophilia are at an increased risk

Asthma: Use with caution in patients with asthma

Cardiovascular disease: Use with caution in patients with cardiovascular disease

Migraine: Use with caution in patients with a history of migraines

Seizure disorders: Use with caution in patients with a history of seizure disorders

Drug Interactions:There are no known significant interactions

Please speak with your doctor or pharmacist about other possible drug interactions as this list is not all-inclusive

Adverse Reactions: Skin irritation where injected, fluid retention and bloating, headache, acne, mood disturbances

Storage: Store at room temperature until mixed with bacteriostatic water. After product is mixed, it must be stored in the refrigerator

Patient Education:

What should I tell my doctor about before taking this medication?

History of blood clots, history of or current heart problems, asthma, cancers, ovarian cysts (females), prostate problems (males), other medications you take including those that are over-the-counter

When and how do I take this medication?

hCG should be injected as directed by your doctor. In females, a single dose is usually given. The egg is released 38-40 hours after an injection of hCG so intercourse or procedures must be timed accordingly. In males, hCG is usually injected 2-3 times per week

hCG can be injected subcutaneously or intramuscularly but subcutaneous injection is preferred for comfort and optimal absorption

What side effects should I call my doctor about right away?

Signs of an allergic reaction like rash, hives, or itching; signs of a blood clot such as pain, swelling, warmth, or numbness in your arm or leg, confusion, extreme headache, weakness on one side